An experiment was conducted for two consecutive years (2012-13 and 2013-14) to determine the effect of different inducer chemicals on spot blotch disease of wheat and its impact on grain yield. All the inducer chemicals reduced the spot blotch infection significantly at different concentration levelsand also increase the yield attributing characters like number of grains/panicle and 1000 seed weight. The accumulation of phenol increased up to 96 days after sowing (DAS), whereas, peroxidase accumulation increased up to 68 days after sowing in wheat plants in all the treatments.Among the different inducer chemicals salicyclic acid (10-4 M) and CuSO4 (10-4 M and 10-5 M) showed good results even at low concentration levels. Therefore, the inducer chemicals can be used as an alternative method to manage the spot blotch of wheat.