Introduction: The field of cancer nano therapeutics is quickly evolving, and it is being used to address a number of issues with traditional drug delivery techniques. The goal of this study was to find out more about the impact of novel bioactive Poria-loaded sun flowers nanoparticles (Poria Nps) as anti-carcinogenic agent for Ehrlich solid tumour (EST). Methods: A total number of 40 adult female mice were divided into 4 groups included control group, Poria Nps group, EST group, and EST treated with Poria Nps group. Results: EST induced toxicity, apoptosis and oxidative stress while treatments of EST with Poria Nps improved this alteration in kidney functions and structure. Moreover, Poria Nps could scavenge free radicals producing beneficial effects against EST induced renal toxicity through activation of oxidative stress and apoptosis. The constructed novel oral nanoparticles developed have promising features in vivo as well as a high level of safety for efficient cancer treatment. Conclusion: Poria cocos nanoparticles (Poria Nps) kill the cancer cells through apoptosis which thereby regulates the proliferation of cancer cells and inhibits its spread to other organs.