Toplumların kaderinde etkili olan ve farklı türlere ayrılan göç olgusu, insan yaşamından bağımsız değerlendirilmeyen edebiyatın da konuları arasındadır. Göçün işlendiği edebi eserlerden biri Adalet Ağaoğlu’nun ikinci kitabı Fikrimin İnce Gülü’dür. Bu çalışmada söz konusu eser bağlamında göç, kişi merkezli olarak “yurt dışına gidenler”, “yurt dışından dönenler” ve “geride kalanlar” şeklinde incelenmektedir. Metne dayalı inceleme yöntemi ile tarihsel ve sosyolojik yaklaşımın ışığında anlatı kişileri odaklı ortaya konulan toplumsal, siyasal, psikolojik ve ekonomik çatışma kaynaklı veriler eser merkezlidir, genelleme yapılmamaktadır. İnsanların beklenti ve hayal kırıklıklarıyla şekillenen Almanya’ya göç sürecinde dağılan/dönüşen aile yapısı, yurtla olan ilişkilerin devamlılığı meselesi, çalışma koşullarının ağırlığı, kültür, dil, din kaynaklı uyumsuzluklar, bireyi yalnızlaşmaya sürükleyen yabancılaşma ve dönüşlerde yaşanan sorunlara değinilir. İki farklı kültür arasında sıkışan, bocalayan, meta kültürün etkisinde tüketim eşyalarına sığınan anlatı kişileri, ekonomik ve sosyal düzene uyum sağlayabilmek için kültürel yozlaşmaya neden olan davranışlar sergilerler. Söz konusu süreci Fikrimin İnce Gülü çerçevesinde inceleyebilmek için göç kuramları arasında bireysel ve toplumsal göç hareketlerini açıklama imkânı veren “çatışma ve göç kültürü” modeli esas alınmaktadır. Bu model bağlamında insanların iç ve dış göç hareketlerinde çatışma, gerilim, zorluk ve anlaşmazlıkların etkili olduğu göz önünde tutularak incelenen eserdeki kişilerin Almanya’ya göç süreci ile sonrasında yaşanan değişimler ortaya konulmaktadır.ABSTRACT IN ENGLISHA Migration Novel by Adalet Ağaoğlu: Fikrimin İnce GülüMigration, a powerful force in societies, is among the topics of literature which is also a part of human life. One of the literary works mentioning migration is Fikrimin İnce Gülü, Adalet Ağaoğlu’s second book. It is possible that the migration can be examined based person as "who go abroad", "turning back" and "survivor" in the text. In the light of text-based inspection method, historical and sociological approaches people-oriented disclosed social, political, psychological and economic conflict is based on only the work, generalization is not done. The transforming family structure, continuity issue of relations with the dormitory, the hardships of the working conditions, discrepancies originated from culture, language, religion, alienation which leads to isolation and the problems in return are discourse in the process that based on people's expectations and disappointments. The characters that trapped between two different cultures, refuge on consumer goods, exhibit behaviours that lead to cultural degeneration to adapt to economic and social order of meta culture. The conflict and migration culture model will prevail in order to examine migration movements in Fikrimin İnce Gülü. In the context of this model, the conflicts of characters in the process of migration to Germany will reveal taking into consideration the difficulties and disagreements to be effective.

Cystic fibrosis (CF) is an autosomal recessive disease. The genetic transition occurs with CF transmembrane conductance regulator (CFTR) gene mutation. We aimed to determine the frequency of CF mutations and also new mutations in the CFTR gene in neonates with respiratory distress. Newborn babies hospitalized due to respiratory distress were included in the patient group. The control group consisted of infants who had no respiratory distress. The CFTR genes of both groups were analyzed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. A total of 40 patients (20 in the patient group and 20 in the control group) were evaluated. The CFTR gene analysis was normal in 16 neonates in the patient group, whereas in others: A46D (c.137C>A) (n = 1), D1312G (c.3935A>G) (n = 1), R117H (c.350G>A) (n = 1), S1426P (c.4276T>C) (n = 1) heterozygotes were detected; CFTR gene analysis was normal at 14 neonates in the control group, whereas in others: E1228G (c.3683A>G) (n = 1), E217G (c.650A>G) (n = 1), E632TfsX9 (c1894_1895delAG) (n = 1), I807M (c.2421 A>G) (n = 2), S573F (c.1718C>T) (n = 1) heterozygotes were detected. There was no significant difference in the patient and control groups’ CFTR gene analysis (p = 0.340). This study demonstrates the importance of CFTR gene analysis in asymptomatic newborn infants for follow-up and early diagnosis of CFTR-related disorders. In this study, a c.1894_1895delAG (E632TfsX9) heterozygous mutation detected in the CFTR gene in an asymptomatic newborn infant, was first encountered in the literature.

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Objectives We aimed to quantitatively analyze lung parenchymal changes in Behçet's patients and to detect early parenchymal quantitative changes that occur in the absence of positive visual radiological findings. Methods In our study, a total of 31 patients with Behçet's disease, 17 with positive radiological findings and 14 patients without positive radiological findings, and a control group of 33 individuals were evaluated. The automatic program determined lung volumes, lung densities, and opacity volume percentages by evaluating the contrast‐enhanced lung computed tomography scans. Results The total lung volume was 3632.98 ± 1100.53 mL in the Behçet's disease patient group and 4925.70 ± 1098.88 mL in the control group, and there was a significant decrease in the total lung volume in Behçet's disease patients (P < 0.0001). The mean lung density was −723.73 ± 65.16 in the Behçet's disease patient group and −767.35 ± 41.17 in the control group, and there was a significant increase in the mean density in the Behçet's patients (P = 0.0023). A significantly higher correlation was observed between lung density and lung volume in Behçet's patients (P < 0.0001, r = −0.795). The lung volume of Behçet's disease patients with negative radiological findings was significantly lower than that of the control group (P = 0.0342). Conclusions Lung volumetric changes in Behçet's disease patients are the quantitative data most affected by the disease. In addition, lung volume decreases in Behçet's patients who do not have visual parenchymal involvement.