In this review article, an attempt has been made for the study of copper, an essential Redox-Active transition metal in living systems. Very least amount of Copper is recognized as a constituent of living system. Detection and estimation of Copper in various living systems have been done and reported by various workers time to time. The presence of Copper is reported more or less in all forms of life. The reported data of work done so far details are available everywhere. This review work is concentrated on its significance of the presence of optimum amount of Copper in living systems. The required particular amount of copper in physiological cycle results thriving, whereas the deviated amount of copper leads to menace in living system, this deviation from the optimum amount makes unhealthy and creates an abnormal condition of metabolic activities in the living systems. This work is totally based on the reports examined the effect of Copper on cellular cycle till today.