Despite the gradual decreases the CE in Ankara and its surroundings, it is still continues to be a major public health problem. Essential prevention and control measures should be taken to reduce the prevalence of the disease. Also in the diagnosis of the disease, more reliable results can obtained with applying two tests (ELISA/IHA) together and confirm the positivity with WB.
Toxoplasma gondii is ubiquitous obligate intracellular parasite and is one of the most important pathogen for humans and animals. In humans, T. gondii has two life forms: tachyzoites and bradyzoites. Tachyzoites form of T. gondii can cause acute infection, and it is called toxoplasmosis. The development of latent bradyzoites from rapidly growing tachyzoites has been linked to cellular and environmental stresses which are associated with heat shock proteins (Hsps). Hsps play a protective role against stressors. Hsp40 is an important member of Hsp family and T. gondii has 36 predicted Hsp40 family members. Therefore, we studied the cloning and biochemical characterization of the T. gondii RH strain Hsp40 protein-Gok1. Hsp40 prevents protein aggregation and induce refolding. Consequently, Hsp40s may play essential roles in the mechanisms of bradyzoite development and survival in the host organism. Hsp40-Gok1 functional and structural properties may facilitate drug design and protein targeting against toxoplasmosis.
ÖZAmaç: Bu çalışmada, Hatay, Burdur ve Kuzey Kıbrıs köpeklerinde leishmaniasisin serolojik olarak araştırılması amaçlanmıştır. Yöntemler: Hatay'dan 124, Burdur'dan 49 ve Kuzey Kıbrıs'tan 105 olmak üzere toplam 278 köpekten kan alınmıştır. Serum örneklerinin dilusyonları hazırlanarak İndirek Floresan Antikor Tekniği (IFAT) ile Anti-Leishmania antikorlarının varlığı araştırılmıştır. Bulgular: Hatay'dan bir (%0,8) ve Kuzey Kıbrıs'tan iki (%1,9) olmak üzere toplam üç köpek (%1,1) seropozitif, yine Kuzey Kıbrıs'tan bir köpek (%0,4) şüpheli pozitif bulunmuştur. Burdur ilindeki tüm köpekler ise seronegatif olarak tespit edilmiştir. Sonuç: Bu çalışma, Hatay ve Burdur illerinde parazitin köpeklerdeki yaygınlığı üzerine yapılan ilk araştırmadır. Hatay'da ve Kuzey Kıbrıs'ta saptanan seropozitiflikler parazitin bu bölgelerdeki varlığını göstermekte ve elde edilen sonuçlar hastalığın yaygınlığı hakkındaki verilere epidemiyolojik açıdan katkı sağlamaktadır. Daha sağlıklı verilerin elde edilebilmesi için, daha geniş köpek popülasyonları ve vektör tatarcık-lar üzerinde araştırmaların yürütülmesi faydalı olacaktır. (Turkiye Parazitol Derg 2016; 40: 9-12
IFAT).Results: A total of three dogs were found to be seropositive (1.1%), one from Hatay (0.8%) and two from Northern Cyprus (1.9%). Also, one dog (0.4%) from Northern Cyprus was found to be borderline positive. All dogs from Burdur have been identified as seronegative. Conclusion: This is the first research on the seroprevalence of the parasite in dogs from Hatay and Burdur. The seropositivity detected in dogs from Hatay and Northern Cyprus demonstrates the presence of the parasite in these regions, and obtained results contribute data on the prevalence of the disease in an epidemiological manner. To obtain more reliable data, it will be useful to conduct studies on wider dog populations and vector sandflies. (Turkiye Parazitol Derg 2016; 40: 9-12).
Objective: This study aimed to pathologically evaluate systemic tissue involvement in acute toxoplasmosis in mice inoculated with Toxoplasma gondii RH Ankara strain.
Several clinical syndromes caused by an obligate intracellular parasite Leishmania spp. subsumed under the term leishmaniasis. Leishmaniasis is endemic in Turkey and the neighboring countries Iran, Iraq, and Syria. Leishmania spp. causes three main clinical forms: cutaneous, mucocutaneous, and visceral disease. The clinical forms may vary by species and/or region of acquisition. Two forms are observed in Turkey; visceral leishmaniasis and cutaneous leishmaniasis. Two cases of cutaneous leishmaniasis with different treatment regimens and a case of visseral leishmaniasis associated with hemophagocytic lymphohistiocytosis are presented in this report.
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