Our data show that pathological Doppler waveforms in the uterine arteries of patients with preeclampsia are paralleled by diminished NOS activity in the uterine placental bed. Therefore, the compromised NO production in the uterine placental bed may play an important role in the impaired uteroplacental blood flow and potentially in some pathological features of preeclampsia such as intervillous thrombosis formation and fetal growth retardation.

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algorithmic treatment and home BP monitoring (HBPM) in men and women <75 years with uncomplicated hypertension (UH). Design and method:Per protocol cohort of PERFECT-BP prospective observational study (ISRCTN75706523) included 430 newly diagnosed (18.3%) or treated but uncontrolled (BP<200/120mmHg) UH patients (pts) aged 57.6 ± 0.5, 197(45.8%) male, 74(17,2%) diabetics. HBPM was performed by standardized automatic Microlife BP3AG1 device with individually selected cuff. At visit 1, pts were given training and written instructions for HBPM and recording (twice per day for 7 consecutive days before each visit) and were prescribed or switched to perindopril/amlodipine fixed-dose combination (FDC) (doses at discretion of MDs).Step 2 was FDC uptitration, step 3 -indapamide SR" step 4 -spironolactone, step 5moxonidine or doxazosin.Results: At baseline men differed from women by younger age (56,1 ± 0,7 vs 59,2 ± 0,6 years, p < 0,01), higher glomerular filtration rate (106,4 ± 2,0 vs 88,3 ± 1,6 kg/m2, p < 0,001), lower incidence of obesity (39,1 vs 59,9%, p < 0,01), higher smoking rate (35 vs 6,7% p < 0,001), higher office and home BP (table). Maximal FDC dose (10/10 mg) prescription obtained 48,7% men vs 33,9% women (p < 0,05), triple therapy -25,4% vs 28,3%, and 4 or more drugs -11,7% vs 9,5% (all p>0,05). By 6 M, target office BP was attained in 145(73,6%) men vs 206(88,4%) women, normal home BP -in 110(55,8%) vs 179(76,8%), both target office and normal home BP -in 104(52,8%) vs 169(72,5%, all p < 0,01). Masked uncontrolled hypertension at 6 M was identified in 41(20,8%) and 37(15,9%) pts, white coat one -in 6(3%) and 10(4,3%) respectively, (all p > 0,05). Conclusions:Standardized algorithmic treatment based on FDC in real life setting provided lower rates of office and home BP control in men compared to women. Sex differences did not affect the incidence of masked uncontrolled and white-coat hypertension.Objective: Systolic blood pressure (BP) has been associated with urinary caffeine and its metabolites such as paraxanthine and theophylline. Caffeine and caffeine metabolites could influence arterial pulse pressure (PP) via sympathomimetic effects, smooth muscle relaxation, and phosphodiesterase inhibition. The purpose of this analysis was to explore the association of ambulatory PP with urinary caffeine and its related metabolites in a large population-based sample.Design and method: Families were randomly selected from the general population of three Swiss cities (2009)(2010)(2011)(2012)(2013). Ambulatory BP monitoring was conducted using validated Diasys Integra devices. PP was defined as the difference between the systolic and diastolic ambulatory BP. Urinary caffeine, paraxanthine, theophylline, and theobromine excretions were measured in 24 h urine using ultra-high performance liquid chromatography tandem mass spectrometry. Urinary excretions were log-transformed to satisfy regression assumptions. We used linear mixed models to explore the associations of urinary caffeine and caffeine metabolite excretions wit...

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