Objective: To evaluate the effect of physiotherapy and its benefits in the clinical outcome of systemic sclerosis. Methodology: This study included two case reports of patients diagnosed with systemic scleroderma, with different levels of clinical involvement. Patients were followed at the premises of the Department of Clinical Physiotherapy, Federal University of Paraíba, from August to December 2011, in sessions lasting approximately one hour, twice a week. Results: Patients showed considerable improvement in thorax expansion, tropism, range of joint movement and hence in quality of life. Conclusion: The physiotherapy resources used in these case reports, such as general and respiratory kinesiotherapy, TENS, hydrotherapy, lymphatic drainage, coordination and balance exercises, among others, provided patients with a favorable clinical evolution.