No abstract

No abstract

The amphiphilic block copolymer poly(styrene-b-N,N-diethylacrylamide) (PSt-b-PDEA) was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization of styrene and N,N-diethylacrylamide. The results of 1 H-NMR and GPC analysis showed that the synthesized PSt-b-PDEA copolymer had controlled molecular weight and narrow polydispersity. Polymeric micelles having a unimodal size distribution with an average diameter of 40 AE 0.5 nm were obtained from purified PSt-b-PDEA using a dialysis method. And the results showed that the clearance of homopolymer in copolymer is the key to prepare the unimodal distribution core-shell nanomicelles. The micelles were thermodynamically stable in aqueous media with a low critical micelle concentration value (0.1 mg L À1 ). The aqueous micelles solution underwent a reversible dispersion/ aggregation transition at around 298C, which corresponds to the lower critical solution temperature (LCST) of the outer shell PDEA block chains. It is hoped that with their unique characteristics, those thermoresponsive polymeric micelles would found application in drug delivery.

No abstract

No abstract