Objective: To date, little research has been done to answer whether people with acute leukemia (AL) experience stigma. No previous studies investigated stigma and its relationship with most common negative emotion and coping styles in patients newly diagnosed as AL. Therefore, the study was designed to find out stigma and its possible contributing factors among the patients with initial diagnosis of AL. Methods: A total of 167 patients newly diagnosed as AL were recruited and investigated by Social Impact Scale (SIS), Medical Coping Modes Questionnaire, Hospital Anxiety and Depression Scale. The data was analyzed by multivariate linear regression to identify influencing factors of stigma. Results: The mean score of SIS was 60.61 ± 9.45, with 13.17% of patients at high level. Almost individuals experienced anxiety or depression during first chemotherapy after diagnosis. The main coping strategy was acceptance-resignation. Patients with following characteristics tend to experienced stronger stigma: male, childless, lower family income, higher degree of dependence, having chronic diseases, more severe depression, and tendency to adopt acceptance-resignation. Conclusions: Patients newly diagnosed as AL were in moderate level of stigma. Effective measures were suggested to alleviate stigma the patients undergoing when struggling for complete remission, especially for those exposed to risk factors of stigma.