Purpose With an increase in the number of adapted sports, the need to monitor sports performance in people with different abilities has grown. Indeed, a thorough evaluation of the sports gesture could prevent the occurrence of injuries, enable a continuous performance assessment, and allow to verify the compliance of the requirements for the competitions. Gesture kinematics provides an assessment of performance, while the muscle activities reveal the underlying strategies adopted by each athlete. In this context, we propose an instrumented evaluation to assess performance in Para-powerlifting. Our goal is to define and test a setup and a protocol to quantitatively assess the execution of bench press exercise in athletes with different abilities. Methods We recruited an unimpaired athlete and three Paralympic athletes. They were requested to execute the bench press exercise while we recorded muscle activity and kinematic data from the upper body. We investigated the sport gesture by extracting parameters describing coordination, symmetry, and synchronism between arms, and motor variability while repeating the gesture. Results Paralympic athletes performed the gestures with higher coordination between arms and low variability across repetitions compared to the unimpaired athlete, who was not at the Olympic level. All participants obtained similar kinematic performance by adopting different muscle strategies. Conclusions This study is a proof of concept that the instrumented evaluation proposed here can allow to conduct a complete assessment of the bench press exercise, in terms of kinematics, muscle activity and performance in athletes with different abilities.