High-resolution human leukocyte antigen (HLA) typing is a time-consuming and expensive process that is typically reserved for hematopoietic stem cell transplantion. Solid organ transplantation currently relies on low-or intermediate-resolution antigen reporting, but recent publications on the value of molecular mismatch analysis highlight the potential role for high-resolution HLA typing in support of clinical decision-making and research in solid organ transplantation. In the absence of available high-resolution typing, investigators have resorted to imputation, focusing on 3 lines of study: (1) assessment of molecular mismatch load as a guide to stratify patients' risk for developing de

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