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Our model reasonably described and predicted the time course of P. aeruginosa in time-kill studies, and provided quantitative information on the pharmacodynamics of meropenem. The structural model appeared robust and could be used to provide a realistic expectation of the killing performance of antimicrobial agents.

A new framework to closed-loop process identification is proposed. It relies on simultaneous constrained model predictive control (MPC) and identification (MPCI