This paper discusses the issue of analyzing the development of cross-border tourism infrastructure in the borderlands of countries with diversified administrative divisions and spatial databases, which hinders the use of national statistical units for comparative research. As an example, the ability to use the square grid and kernel density estimation methods for the analysis and spatial visualization of the level of tourism infrastructure development is studied for the Orlickie and Bystrzyckie Mountains, located in the Polish–Czech border area. To synthetically assess and compare the level of diversity, the methodology used in the Human Development Index was adapted using selected component indicators calculated for a square grid clipped to the boundaries of the area under study. This analysis enabled us to quantify the asymmetry in the development of tourism infrastructure in the borderlands via the calculation of the synthetic infrastructure development index. This index is 1.29 times higher in the Czech than in the Polish border area. However, the spatial concentration analysis of infrastructure shows that the diversity in the study area can be assessed as higher than the results using the average density indicators. This paper also discusses the benefits and problems associated with using the square grid method for the representation and analysis of heterogeneous data on tourism infrastructure in two neighboring national states.