The innovativeness boosted by incubator centers has an important role in the sustainable development of the country and its regions. The paper describes a comparative analysis of the effectiveness of the business incubator center on the economic growth of a region. The goal of the paper is a comparison between two business incubators, CAN-BE in Hazleton, PA USA and Technopark in Gliwice, Poland. A number of indicators were used to measure economic growth. These selected indicators reflected social, organizational, technical, and financial aspects of economic growth.