HSV-1 DNA was detected in 32 (30%) of 106 cerebrospinal fluid samples from patients with encephalitis. Cytomegalovirus, varicella-zoster virus, and human herpesvirus 6 (HHV-6) DNAs were each detected in three patients (3%); herpes simplex virus type 2 (HSV-2) and HHV-7 PCRs were negative. HSV detection was associated with seizure (P ؍ 0.02), especially focal seizure (P ؍ 0.0002), and pathological computed tomography (P ؍ 0.02) with focal lesions (P ؍ 0.0004).
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