Introduction: Hopf's verruciform acrokeratosis is a genodermatosis characterized by keratotic lesions on the dorsa of the hands and feet. It usually develops during childhood but can occasionally develop at later ages, even in the fifth decade. Case report: We present the case of a 34-year-old man with phototype IV, who presented with cutaneous lesions that affected the forearms and hands on the dorsal surface, with a tendency to symmetry, consisting of multiple skin-coloured keratotic papules and erythematous lesions, of different sizes, some with a tendency to converge, rough surface with well-defined edges. The lesions were characterized by a chronic evolution. Conclusions: Because of its low prevalence, there are still no treatment guidelines, however topical or oral retinoid treatment, as well as laser and cryotherapy, are useful. The disease is prone to recurrence.

Leprosy, or Hansen’s disease, is a chronic infectious disease with a low transmission rate, affecting the skin, peripheral nerves, eyes, and mucous membranes of the upper respiratory tract, yet it may also be systemic. Cases of borderline leprosy are the acute or subacute stages of the disease. They are immunologically unstable and reflect the gradual variation in resistance against the etiological agent. Localized scleroderma or morphea is a fibrosing disease of the skin and underlying tissues that results from the disrupted function of growth factors (platelet-derived growth factor, i.e., PDGF) and receptor expression (as in the case of transforming growth factor b, i.e., TGF-b). Herein, we report a female patient with borderline tuberculoid leprosy (BT) who, during multidrug treatment (MDT), developed an indurated lesion of morphea exactly on the surface of an infiltrated patch.