Review question / Objective: To test the effectiveness of multimodality therapy using minoxidil and micmroneedling, in comparison to minoxodil alone for the treatment of alopecia. In terms of the PICO framework: Population: Includes patients with any form of clinically diagnosed alopecia. Intervention: Includes using combination therapy with microneedling and minoxidil in the treatment of alopecia. Comparison: Includes comparison to minoxidil alone as control group. Outcome: Primary outcome: Increased hair density. Secondary outcome: Increased hair diameter. Condition being studied: Alopecia (hair loss) is a condition that is frequently seen in dermatology. When a thorough examination is made, the root of the issue is frequently revealed, allowing for an explanation and the most suitable treatments. Nevertheless, hair loss can occasionally be the first indicator of a serious underlying medical problem, be observed in conjunction with other conditions, or be a side effect of treatment. Furthermore, alopecia may result in distressingly noticeable symptoms, cause significant patient distress, and cause alopecia with lifelong scars and irreversible hair loss. Therefore, with these illnesses, a precise diagnosis and quick therapy are essential for the most beneficial outcomes.