Background: Platelets mediate inflammatory activity through release of CD40L. Results: CD40L expression in platelets is regulated by NFATc2 and EGR-1 activation in megakaryocytes. Conclusion: Platelet inflammatory activity is dynamically regulated by exogenous factors that control NFAT and EGR-1 activity in megakaryocytes. Significance: The NFAT/EGR-1 axis in megakaryocytes may be a new target for treatment of chronic inflammatory diseases.
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