Aims: The aims of the study were to: assess job satisfaction, burnout, compassion satisfaction, and work-related stress among pediatric nurses at surgical, medical, critical care, and hematology/oncology units in a tertiary acute care hospital; and identify the predictors of job satisfaction, burnout, compassion satisfaction, and work-related stress. Results: Nurses in the hematology/oncology unit reported the lowest level of burnout and highest levels of job satisfaction and compassion satisfaction. In contrast, nurses in the surgical unit reported the opposite. Among surgical unit nurses, those with 5-9 years of RN experience reported highest burnout as well as lowest job satisfaction and compassion satisfaction. The combination of demographic variables explained a large fraction of the variance in job satisfaction (R 2 = 0.251) and positive predictors were white ethnicity (β = 0.33) and hematology/oncology unit (β = 0.16), whereas negative predictors were surgical unit (β = -0.32) and critical care unit (β = -0.20). Methods Conclusions:Nurses in the hematology/oncology unit reported lowest burnout and highest job satisfaction, which may be due to the educational and mentoring support from a unit-based end-of-life care program. A focused strategy targeting a specific group of nurses in a unit may help to reduce work-related stress and burnout.