Dento-maxillary anomalies are relatively widespread among the population, eventually leading to serious psychological and lifestyle deterioration. The purpose of this paper is to evaluate the complex orthodontic-surgical treatment in the dento-maxillary anomaly class III Angle. We aim to present the clinical case of a female patient suffering from skeletal third-class, gnathic form, who came to „Omni Dent” clinic in order to complete the second stage of associate orthodontic and surgical treatment. Medical investigations: OPG, CBCT, TRG, digital scanning, dental photography, digital programs, used at collecting data for virtual planning, establishing a complex diagnosis and choosing the best surgical technique for this case, subsequently, with the transfer of the virtual plan in the operating room through surgical guides and occlusal splints. Postoperatively, there was an obvious improvement of the facial appearance, supported by the comparison of pre- and postoperative cephalometric indices: SNA (from 76,6° to 84°), SNB (from 80,6° to 78,8°), ANB (from -4° to 5,2°), Wits (from -9,6° to 0°). Early diagnosis and detailed planning by using modern methods of examination may ensure an efficient rehabilitation of patients suffering from dento-maxillary anomalies.