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Aim. To determine the content of heat shock proteins with molecular weight 70 kDa (HSP 70) and antibo dies to them in blood and nasal secretion in patients with allergic rhinites and infectious rhinosinusites of different etiology. Materials and methods. The paper presents the results of examination of 10 patients with allergic rhinitis and 30 patients, infected with rhinosinusites(the age range 25–35 years). The patients with infectious rhinosinusites were divided into 3 groups according to nosologic form of disease. The control group included 10 practically healthy persons in the ratio, comparable by their gender and age with sick persons. Results.The analysis showed that in the nasal secretion of all patients, HSP 70 level significantly raised compared to the control. Maximum values were registered in patients with bacterial rhinosinusitis and were higher than in patients with viral and fungous ones by 1.9 times (p = 0.015) and 2.9 times (p = 0.001), respectively. In blood serum, HSP 70 concentration compared with the control increased in patients with allergic rhinitis and bacterial rhinosinusitis by 103.67 % (p = 0.015) and 32.11 % (p = 0.049), respectively; these values in the last two groups exceeded the latter in patients with fungous RS by 2.37 times (p = 0.01) and by 1.54 times (p = 0.035). Conclusions. It was detected that in the group of patients with allergic rhinitis and chronic bacterial rhinosinusitis in the nasal secretion and blood serum, HSP 70 values were the highest. In the nasal secretion, HSP 70 level was higher than in blood. The amount of autoantibodies to HSP 70 in blood grew in allergic rhinitis, fungous and viral forms of rhinosinusites that reflects the immunological effect of chaperone proteins.

Despite the fact that women have lower incidence of non-ST-elevation myocardial infarction (NSTEMI) compared with men, they have a higher mortality, attributed to the impact of the age, higher burden of comorbidities, atypical symptoms and possible differences in the diagnosis and treatment of NSTEMI. Based on this, we aimed to evaluate the sex differences in the clinical presentation, management and major adverse cardiovascular events (MACE) of patients presenting with NSTEMI in the Republic of Moldova. Data were collected from the observational studies: retrospective (2019) and prospective (2020-2021), conducted in 3 PCI centers in Moldova, which included 351 consecutive patients with the clinical diagnosis NSTEMI. The data obtained were processed by descriptive statistical methods, using the t-test, the Pearson χ² test and the p-value. After analyzing the obtained results, we concluded that women had a lower incidence of NSTEMI, but had a higher rate of risk factors and comorbidities, compared to men, they presented more frequently atypical symptoms and more often had myocardial infarction with non-obstructive coronary arteries (MINOCA). At the same time, several gaps in the management of women with NSTEMI in the Republic of Moldova were highlighted. MACE proved to be similar at both sexes, but with a higher mortality at women. These data guide us to the need of a comprehensive approach of women with NSTEMI, taking into account the gender particularities in the clinical presentation and management of the disease.