The prevalence of clopidogrel resistance in our East European population was in line with that reported for Western populations. Clopidogrel response was significantly influenced by the presence of CYP2C19 polymorphisms. Interestingly, the concomitant use of aspirin had a significant impact on platelet response to clopidogrel, indicating a synergic interaction between these drugs.

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Obesity is a problem with great importance and certain actuality in the field of paediatric pathology because of its increased incidence in children and its complications. Fat mass and obesity associated (FTO) genes are related with weight gain and obesity during childhood, being correlated with body mass index (BMI) and leptin levels.The aim of our study was to establish the role of the polymorphisms of rs9939609 and rs17817449 FTO genes in determining obesity in a child population from Romania. Methods We assessed 225 hospitalised children in a tertiary emergency paediatric hospital divided into: control group -110 patients with normal nutritional status and obese group -105 patients. The two groups underwent the evaluation of FTO rs17817449 and rs 9939609 SNP, and the measurement of anthropometric parameters [ Background and aims Reactive hyperemia-peripheral artery tonometry (RH-PAT) is a non-invasive method for endothelial function assessment. The goal of this study is to investigate endothelial function as assessed with the RH-PAT in control adolescents and adolescents with type 1 diabetes (T1D) or overweight. Methods RH-PAT score and baseline pulse amplitude was measured after an overnight fast in 25 control subjects (age 12-20 years), 34 adolescents with T1D and 27 adolescents with overweight or obesity.Results RH-PAT score was lower in adolescents with T1D compared to healthy controls ( 1. Conclusions Endothelial dysfunction, quantified by lower RH-PAT score or higher baseline pulse amplitude, was observed in both adolescents with T1D and with overweight. Early detection of vascular changes in these high-risk patient groups may allow targeted interventions to reduce cardiovascular disease in adulthood.

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screened the allelic frequencies of (GT) n repeats in the HO-1 gene promoter in these obese children. NAFLD was determined through liver ultrasonography. Because the distribution of numbers of (GT) n repeats was bimodal, we divided the alleles into 2 subclasses: class S included shorter (n repeats in HO-1 gene promoter on paediatric NAFLD. Results Of 101 obese subjects, 27 (26.7%) had NAFLD. The alanine aminotransferase (ALT) level was higher in patients carrying L alleles