MH designed and performed experiments and interpreted results.. L.A. designed and performed the in vitro experiments, M.A.M., designed and performed the in vivo experiments, L.C-E., the hydroxymethylation and EdU stainings, G.B, experiments with small molecule inhibitors. G.V. and E.A.M. prepared and analysed WGBS and RRHP libraries, analysed RNAseq and interpreted corresponding bionformatic analyses related. N.A., A.R. and S.J.F. performed experiments with β1 integrin model and interpreted results of the p21 models. J.v.d.A. and A.H.B. performed DamID-seq experiments. B.F-C helped on the in vivo analysis. R.A.C. helped on bioinformatics analyses. R.L.M. provided the R26Fucci2a line. F.A. and M.Z.G. performed the live imaging of ductal cells.