Compared to an office-based case-finding strategy, the two-step systematic screening strategy had no overall effect on fracture incidence. The two-step strategy seemed, however, to be beneficial in the group of women who were identified by FRAX as moderate- or high-risk patients and complied with DXA.
Locally derived reference values are important to avoid false positive or false negative findings during work-up in patients evaluated for osteoporosis.
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