The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize procedures to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient. description of the evidence collection MethodThis guideline followed the standard of a systematic review with evidence retrieval based on evidence-based medicine (EBM), so that clinical experience is integrated with the ability to critically analyze and apply scientific information rationally, thus improving the quality of medical care.We used the structured mode of formulating questions synthesized by the acronym PICO, where P stands for patients with prostate cancer, I stands for indicator, i.e., radium-223, and O stands for outcome, which is benefit.Based on the structured question, we identified the descriptors that formed the basis of the search for evidence in the databases: Medline-Pubmed. Ninety-nine (99) studies were retrieved and, after applying the eligibility criteria (inclusion and exclusion), 13 were selected to answer the clinical question (Annex I).clinical question