No abstract

The aldol addition of readily enolizable 1,3-dicarbonyl compounds to 2-cyanobenzaldehyde in the presence of a tertiary amine led to a series of new 3-substituted isoindolinones. Despite the instability of the related aldols, this synthesis was possible because of the intramolecular trapping of the adducts with the cyano group due to a tandem process of cyclization and rearrangement. Simple decarboxylation of some derivatives gave access to very useful compounds.

The Aldol Addition of Readily Enolizable 1,3-Dicarbonyl Compounds to 2-Cyanobenzaldehyde in the Synthesis of Novel 3-Substituted Isoindolinones. -(MORE, V.; DI MOLA, A.; PERILLO, M.; DE CAPRARIIS, P.; FILOSA, R.; PEDUTO, A.; MASSA*, A.; Synthesis 2011, 18, 3027-3031, http://dx.doi.org/10.1055/s-0030-1260125 ; Dip. Chim. Biol., Univ. Salerno, I-84084 Fisciano, Salerno, Italy; Eng.) -Mais 05-121

Synthesis of -Amino Acids 3-Substituted Phthalides or Isoindolinones. -(PERILLO, M.; DI MOLA, A.; FILOSA, R.; PALOMBI, L.; MASSA*, A.; RSC Adv. 4 (2014) 9, 4239-4246, http://dx.