Background and objective: Sclerosing pneumocytoma is a rare, benign tumor of the lung that represents a diagnostic challenge due to the diversity of pathohistological findings. The aim of this study was to present a 10-year experience with sclerosing pneumocytoma of a large center for the diagnosis and treatment of pulmonary diseases, and to emphasize differential diagnostic dilemmas as a potential source of errors. Material and Methods: This represents a retrospective study of six patients diagnosed and treated with sclerosing pneumocytoma in the 10-year period. The study analyzed various parameters, which are: Sex, age, symptoms, size and localization of the tumor, and its gross and histological features. Results: Sclerosing pneumocytoma was more frequently diagnosed in females (83.34%). The patients ranged in age from 38 to 61. Most of the patients (66.66%) were asymptomatic. Two patients underwent a video-assisted thoracoscopic surgery, two patients had a video-assisted minithoracotomy, and two patients underwent a thoracotomy in order to remove the tumor. The tumor was localized in the left lower lobe, in the right upper lobe, and in the right lower lobe in 50%, 33.34%, and 16.66% of patients, respectively. The tumor size ranged from 1 to 2.5 cm. A pathohistological examination of all six cases reported that all four major histological patterns were found in tissue sections: solid, papillary, sclerosing, and hemorrhagic. In all six cases, an immunohistochemical analysis showed positive expression of TTF-1 and panCK in surface epithelial cells, and TTF-1 positivity and panCK negativity in round stromal cells. Conclusions: Sclerosing pneumocytoma is a strictly histological diagnosis supported by clinical and radiological findings and corresponding immunohistochemical methods. Lung pathologists should always keep this tumor in mind, since its spectrum of differential diagnosis is wide, and therefore it can be an important diagnostic pitfall.

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Background/Aim. The histological phenomenon of tumor budding is being recognized as an important determinant of disease progression and poor prognosis in various types of carcinoma. We aimed to evaluate the clinicopathological significance of tumor budding in adenocarcinoma of the lung. Methods. The study included 114 patients, operatively treated for lung adenocarcinoma in one-year period. Microscopic analysis of routine histological slides was performed to establish the presence and density of tumor buds. These results were compared to gender, age, tumor size, nodal status and pathological stage. Results.The budding-positive group included 34 men (53.1%) and 27 women (54%). There were 30 men (46.9%) and 23 women (46%) in the budding-negative group. There was no statistical significance found between males (64.3 ± 6.59) and females (63.1 ± 6.53) in the buddingpositive group, nor in the budding-negative group (males 63.3 ± 6.02; females 63.2 ± 6.72), age considering. Statistically significant result in tumor size was found in females with the presence of tumor budding (p<0.05). Budding-positive group of patients in nodal status N1 and in stage III of the disease pointed to the statistical significance (p<0.05). Conclusion.With statistical significance confirmed between higher nodal status, higher pathological stage and tumor budding found in this study, this histological phenomenon is still relatively new for diagnostics domain of pathology, but receiving increasing attention as an adverse prognostic factor. These results may help tumor budding to incorporate into existing staging systems as it is associated with other factors known to portend worse outcome. ApstraktUvod/Cilj. Fenomen tumorskog pupljenja sve više biva prepoznat kao značajna determinanta progresije i loše prognoze različitih tipova karcinoma. Cilj studije je bila kliničko-patološka evaluacija ovog fenomena u adenokarcinomu pluća. Metode. Studija je obuhvatila 114 pacijenata operisanih od adenokarcinoma pluća u jednogodišnjem periodu.Mikroskopskom analizom preparata analizirani su prisustvo i gustina tumorskih pupoljaka prema metodologiji Uena i saradnika. Dobijeni rezultati su poređeni sa polom, starošću, veličinom primarnog tumora, nodalnim statusom i stadijumom bolesti. Rezultati. U odnosu 4 na pol, u grupi ispitanika sa potvrđenim prisustvom tumorskog pupljenja bilo je 34 (55,7%) muškaraca i 27 (44,3%) žena. U grupi ispitanika bez prisustva tumorskog pupljenja bilo je 30 (56,6%) ispitanika muškog i 23 (43,4%) ženskog pola. Nije uočena statistički značajna razlika u godinama između muškog (64,3 ± 6,59) i ženskog pola (63,1 ± 6,53) kod pacijenata sa prisustvom tumorskih pupoljaka u tumorskom tkivu, kao ni kod muškog (63,3 ± 6,02) i ženskog pola (63,2 ± 6,72) kod pacijenata bez prisustva tumorskog pupljenja.Statistički značajna razlika nije pronađena ni u veličini tumora među pacijentima sa (4,4 ± 2,34) i bez prisustva tumorskog pupljenja (4,2 ± 2,18). Dominantna je grupa ispitanika sa nodalnim statusom N1 u čijem je tumorskom tkivu dokazan fenome...