Maternal mortality is one of the indicators of health-care quality and effectiveness. Maternal mortality increases and decreases due to several factors. This article aims to analyze the factors that cause the increase and decrease in the maternal mortality rate. The research method is a cohort prospective, using a systematic sampling technique with the principle of proportionality. The number of samples is 150 data taken from the Tapin District Health Office, South Kalimantan, Indonesia. Statistical data analysis was performed using statistical descriptions and statistical inferential. The results of hypothesis testing indicate that age, early detection, K1 – K4 visits, integrated ANC and 3x SpOG ultrasound have a significant effect on maternal mortality. The parity does not have a significant effect on maternal mortality. Therefore, the pregnancy program must pay attention to age. During pregnancy, pregnant women must go through the process of early detection, K1 – K4 visits, integrated ANC.Parity must be considered so that babies can be born with conditions without deficiencies. Keywords: Age; Parity; Early Detection; K1 – K4 Visits; ANC, Ultrasound; Maternal Mortality.