The structures and components of different pigments from the Feng Hui tomb situated in Bin County, Shaanxi Province, dated in the Five Dynasties (907-960 AD), were analyzed by Raman spectroscopy and high-resolution electron microscopy (HREM). It is shown that the red, yellow and black samples are cinnabar, PbSO 4 -PbO and carbon black, respectively, and well preserved, which provide scientific data for later conservation. Moreover, the results indicate that HREM and Raman analysis are very effective for identifying ancient inorganic pigments at low concentrations.

No abstract

No abstract

Rationale: ORCT drug instructions display, OCRT can induce a rare adverse reaction of systemic tremor. Patient after taking a series of drugs and OCRT, the patient experienced adverse event of systemic tremor. Hence, we hypothesize that tremor is caused by OCRT. Patient concerns: An 83-year-old male patient a hard mass sized about 5 cm × 3 cm could be touched on the inner side of anterior superior spine of left lower abdomen, local tenderness. Diagnosis: 1. Abdominal distension and poor appetite to be checked; 2. Previous operation for bladder cancer; 3. Acute exacerbation of chronic obstructive pulmonary disease; 4. Arteriosclerotic encephalopathy; 5. Prostatic hyperplasia; and 6. Sleep disorders. Interventions: After hospitalization, the patient was given symptomatic treatment with Corydalis Yanhusuo analgesic pills and Shubitong capsules. On October 29, the patient's pain was still poorly controlled, so OCRT (10 mg, q12h PO) was given. On November 2, the dose of OCRT was adjusted to 20 mg, q12h PO. At 13:00 on November 3, the patient suffered from dizziness and systemic tremor for more than 5 h. On November 4, the patient suffered from dizziness and systemic tremor, without apparent neurological signs. Outcomes: On November 4, OCRT was discontinued, and morphine sulfate controlled-release tablets (30 mg, q12h PO) were administered. MRI examination: No abnormal findings on craniocerebral DWI scans; EEG examination: Abnormal findings, epilepsy was excluded temporarily. On November 4, the tremor in patient was improved. On November 5, the patient no longer complained of tremor. Lessons: Correlation analysis between the tremor and the case suggested that the tremor was an adverse reaction caused by OCRT. According to our analysis, relevant mechanism of action was probably associated with the lowered secretion of γ-GABA and NE caused by the action of OCRT on μ receptors, which led to rhythmic, involuntary tremor of muscles in one or more functional areas. Or it may be that the OCRT caused excessive production of 5-HT to induce the 5-HT syndromic tremor.

The aim of this study was to systematically evaluate the correlation between the rs231775 locus polymorphism in the cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene and genetic susceptibility to Graves’ disease (GD) in children. Some studies found that the CTLA-4 gene polymorphism was associated with GD in children. The data up to February 2022 were retrieved from the databases. Stata 15.0 software was used for meta-analysis. A total of seven studies were included in our research. The results of the meta-analysis showed that the rs231775 locus polymorphism in the CTLA-4 gene in general and Asian populations was correlated with children’s susceptibility to GD (A vs G: OR = 0.75, 95% CI (0.660–0.86); GG vs AA: OR = 1.34, 95% CI (1.04–1.73); AG vs AA: OR = 1.32, 95% CI (1.02–1.10); AG + GG vs AA: OR = 3.81, 95% CI (2.17–6.70); GG vs AA + AG: OR = 1.23, 95% CI (1.05–1.45)). In summary, the rs231775 locus polymorphism in the CLTA-4 gene may be a risk factor for GD in Asian children. The G allele may be a susceptibility factor, while the allele A may be a protective factor against GD in Asian children. In the future, more large-scale studies may be needed to verify our results.