A novel
nickel-catalyzed highly selective reductive cross-coupling
of alkyl bromides and chlorosilanes to construct the C–Si bond
has been developed. Under benign reaction conditions, a series of
structurally interesting organosilanes can be accessed without Ni-catalyzed
isomerization. The utility of this chemistry is illustrated by further
transformations of the product. Moreover, the radical mechanism of
the reaction is illustrated by control experiments.
The
palladium-catalyzed highly regio- and diastereoselective arylboration
of alkenylarenes has been developed. This chemistry afforded the benzylic
boronic esters with a broad substrate scope, which are valuable synthetic
intermediates for organic synthesis. The chiral anion phase-transfer
strategy was designed for this transformation to realize the regio-,
diastereo-, and enantioselective control of this reaction simultaneously.
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats: possible mechanisms, promotes the expression of growth factors, regulates NOS activity, promotes collagen deposition, and reduces inflammatory factors.
A novel high regio- and diastereo-selectivity reductive functionalization of 1,3-diene has been developed using H2O as a stoichiometric hydrogen atom donor.
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