Chronic alcohol consumption causes hepatic steatosis, which is characterized by a considerable increase in free fatty acid (FFA) and triglyceride levels. To identify the possible proteins involved in the progression to alcoholic hepatosteatosis, we performed proteomic analysis on livers of mice exposed to alcohol. 2D-based proteomic analysis revealed that EtOH exposure in mice changed the expression of 43 proteins compared with that in mice fed a normal diet (ND). The most notable protein changes were proteins involved in Met metabolism and oxidative stress, most of which were significantly downregulated in alcohol-exposed animals. Although non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) seem to share the same molecular processes, the difference between these conditions is still unclear. To address this question, we explored the features of alcoholic hepatosteatosis that were different compared with those of methionine and choline deficient (MCD) diet-induced mice with nonalcoholic liver damage. Although most of the differentially expressed proteins associated with ALD did not significantly differ from those of NAFLD, nine proteins showed considerably different patterns. Of these, ornithine aminotransferase, vitamin D binding protein, and phosphatidylethanolamine-binding protein were considerably upregulated in ALD mice, compared to that in NAFLD and ND mice. However, other proteins including inorganic pyrophosphatase were differentially regulated in MCD mice; however, they did not differ significantly between the alcoholic model and ND control mice. These results suggested that the identified proteins might be useful candidate markers to differentiate ALD from NAFLD. J. Cell. Biochem. 118: 1189-1200, 2017. © 2016 Wiley Periodicals, Inc.

Purpose: This study was designed to investigate the impact of the elderly's basic psychological needs and wisdom on successful aging. Methods: The study participants were 150 elderly people aged at least fifty five years of age. The participants were drawn from six welfare centers serving the elderly located in Gwangju metropolitan city, Naju city, and Jeonnam province from February 2017 to March 2017. Data were collected by three self-report questionnaires measuring successful aging, basic psychological needs, and wisdom. For data analysis, SPSS/WIN 18.0 program was utilized including one-way ANOVA, independent t-test, Pearson correlation coefficients, and multiple regression. Results: This study showed a positive correlation between successful aging and basic psychological needs (r=.75 p<.001), wisdom (r=.74 p<.001). In addition, successful aging has a positive correlation with autonomy (r=.32 p<.001), competence (r=.77 p<.001), and relationship (r=.73 p<.001). The competency (β=.40), relationship (β=.18), wisdom (β=.34) have a 69% (F=96.38, p<.001) explanatory power for the successful aging in the elderly. Conclusion: The findings suggest the necessity to support the basic psychological needs of the elderly in order to support wise lives.