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What is known and objective We investigated the elimination efficiency and pharmacokinetics (PK) parameters of vancomycin (VCM) in patients undergoing continuous haemodiafiltration (CHDF) using a polyethyleneimine‐coated polyacrylonitrile membrane (AN69ST) for dosage adjustment. Methods We conducted a retrospective study of CHDF patients treated with VCM from December 2017 to August 2019. We calculated PK parameters of VCM and determined the 24‐hour dose required to maintain the target trough concentration of VCM (VCM_trough). Results and discussion The average (95% CI) volume of distribution and total clearance of VCM were 75.5 L (63.7‐87.3 L) and 1.84 L/h (1.38‐2.30 L/h), respectively, and the elimination rate constant and half‐life were 0.026/h (0.017‐0.034/h) and 31.2 h (22.8‐39.5 h), respectively. The average AN69ST clearance of VCM (CL_CHDF) was 0.69 L/h (0.52‐0.86 L/h). The estimated average doses required to maintain VCM_trough of 10, 15 and 20 μg/mL were 623.1 mg (379.8‐866.4 mg), 934.6 mg (569.7‐1299.5 mg) and 1246.2 mg (759.6‐1732.8 mg), respectively. What is new and conclusion The PK of VCM and CL_CHDF of AN69ST were clarified. These results suggest that it is possible to adjust the dose of VCM in using AN69ST, which efficiently removes cytokines, and contributes to improvement of serious infections.