BACKGROUND AND PURPOSE:Quantitative susceptibility mapping of the human brain has demonstrated strong potential in examining iron deposition, which may help in investigating possible brain pathology. This study assesses the reproducibility of quantitative susceptibility mapping across different imaging sites.

The steady-state free precession (SSFP) method has been shown to exhibit strong potential for distortion-free functional magnetic resonance imaging (fMRI). One major challenge of SSFP fMRI is that the frequency band corresponding to the highest functional sensitivity is extremely narrow, leading to substantial loss of functional contrast in the presence of magnetic field drifts. In this study we propose a frequency stabilization scheme whereby an RF pulse with small flip angle is applied before each image scan, and the initial phase of the free induction decay (FID) signals is extracted to reflect temporal field drifts. A simple infinite impulse response (IIR) filter is further employed to obtain a low-pass-filtered estimate of the central reference frequency for the upcoming scan. Experimental results suggest that the proposed scheme can stabilize the frequency settings in accordance with field drifts, with oscillation amplitudes of <0.5 Hz. Phantom studies showed that both slow drifts and fast fluctuations were prominently reduced, resulting in less than 5% signal variations. Visual fMRI at submillimeter in-plane resolution further demonstrated 15% activation signals that were nicely registered in the microvessels within the sulci. It is concluded that the IIR-filtered frequency stabilization is an effective technique for achieving reliable SSFP fMR images at high field strengths. Magn Reson Med 57:369 -379, 2007.