In this paper, experimental and finite element methods are integrated to carry out the research about residual strength of composite laminate structure with central and edge notch. First, the specimens with central and edge notch and the fixtures used in compression tests were designed and manufactured, and the tensile and compression residual strengths with different notch size were measured. Then, finite element analysis model of specimens with central and edge notch were established to predict the residual strength based on the average stress criterion and Hoffman criterion, the effect of the notch size on the residual strength is evaluated, the results were compared and found that the average stress model has higher prediction accuracy and notch size has a significant influence on the residual strength of composite laminate structure with central and edge notch.