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The Nongtun ore deposit, located in the northwest of the Ag-Pb-Zn polymetallic district in Xidamingshan, Guangxi, is a large-scale Pb-Zn deposit. It is a newly discovered deposit in the southwest edge of the Qin-Hang metallogenic belt, for which some aspects of its genesis are still poorly understood, such as the origin and evolution of the mineralizing fluids, the precipitation mechanisms, and the genetic type. This paper draws on detailed field investigations together with new data from fluid inclusions, with a view to understanding the characteristics of ore-forming fluid and the genetic types of ore deposit.