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This paper summarizes the mitigation strategies for the thermal runaway of lithium-ion batteries. The mitigation strategies function at the material level, cell level, and system level. A time-sequence map with states and flows that describe the evolution of the physical and/or chemical processes has been proposed to interpret the mechanisms, both at the cell level and at the system level. At the cell level, the time-sequence map helps clarify the relationship between thermal runaway and fire. At the system level, the time-sequence map depicts the relationship between the expected thermal runaway propagation and the undesired fire pathway. Mitigation strategies are fulfilled by cutting off a specific transformation flow between the states in the time sequence map. The abuse conditions that may trigger thermal runaway are also summarized for the complete protection of lithium-ion batteries. This perspective provides directions for guaranteeing the safety of lithium-ion batteries for electrical energy storage applications in the future.