No abstract

No abstract

Introduction The efficacy of molnupiravir (MLN) on Omicron sublineages is limited. We investigated the effectiveness of MLN in older adults diagnosed with Omicron BA.2. Methods Data of elderly COVID-19 patients (over 60 years) admitted to Chinghai Hospital (Shanghai, China) from 26 March to 31 May 2022 were reviewed. Study outcomes were a composite of undetectable viral load (VL) and disease progression [all-cause mortality, initiation of oxygen supply through high-flow device or invasive mechanical ventilation (IMV), or intensive care unit (ICU) admission] and their individual outcomes. Results A total of 42 elderly patients were enrolled: 26 of them received MLN, 17 (40.5%) were males, the median age was 84 years, and 12 were fully vaccinated (31.0%). Among these elderly COVID-19 patients, five (11.90%) experienced obvious dyspnea or were transferred to ICU [three MLN users (11.5%) versus two non-MLN users (12.5%)]. Compared with no MLN use, MLN use was associated with rapid undetectable VL. At day 10, MLN users achieved significantly greater undetectable VL than non-MLN users. Adjusted analysis showed that elderly patients who received MLN were 7.584 times more likely to achieve undetectable VL at day 10 than non-MLN users. Overall, elderly patients experienced a median hospital stay of 13 days. Compared with patients receiving standard care (SC), the median hospital stay of MLN users was reduced by 2.5 days. Conclusion Early initiation of MLN in elderly COVID-19 was associated with fast undetectable VL and short hospital stay.

Based on the ten classifications of assets, we use different hyperbolic efficiency decreasing parameters and average service life, respectively simulate the age-efficiency function, age-price function and age-depreciation rate function of the ten major asset groups to estimate the net capital stock of China, and then recalculate the total factor productivity. This study finds that since 1978, China's net capital stock has increased significantly, it has increased from 497.7 billion yuan in 1978 to 15,847.6 billion yuan in 2016, with an average annual growth rate of 9.5%. And the growth rate of TFP has been declining in general since 1992, then it has gradually stabilized at more than two percentage points around 2012, and the average contribution rate has remained above 30%.Compared with other studies using the gross capital stock to overestimate the TFP, the results of this paper can help to understand the real situation of TFP in China. This study promotes the capital accounting from the gross accounting to the net accounting, and is of great significance for the preparation of national and local balance sheets.

Concrete, one of the sources of energy consumption and carbon emissions, is widely used in the construction industry. The selection of concrete materials raises the question of energy sustainability and turns it into a complex multicriteria decision-making (MCDM) issue. To address this, we present an MCDM framework based on the intuitionistic linguistic hybrid weighted logarithmic averaging distance (ILHWLAD). To begin with, the intuitionistic linguistic numbers are used to deal with the uncertainty and fuzziness of the decision-making process. In addition, in view of the significance and the ordered position of the input arguments, an intuitionistic linguistic hybrid weighted logarithmic averaging distance (ILHWLAD) operator is defined. We, then, initiate the criteria system and present the MCDM framework based on the ILHWLAD to select the finest concrete. A case study involving four alternative materials, namely, autoclaved aerated concrete (AAC), hollow concrete blocks (HCB), expanded polystyrene (EPS), and lime hemp concrete (LHC), is presented to verify the scientificity of the framework.