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Objective: To determine the correlation between knowledge and implementation of evidence-based practice among nurses at Ho Chi Minh City Oncology Hospital. Subjects and research methods: A cross-sectional descriptive study was conducted on 194 nurses working at Ho Chi Minh City Oncology Hospital from January 2022 to May 2022. Data were collected using a questionnaire. The research subjects were selected by stratified random sampling method. Descriptive statistics and Pearson correlation were used to analyze the data. Results: The majority of nurses participating in the study were female (83%). The mean age of nurses was 34.46 ± 6.6 years. The mean of work experience is 11.77 ± 6.47 years. The highest mean score of knowledge was 5.12 ± 0.74, followed by practice at 4.90 ± 0.99. There is a strong correlation between knowledge and implementation of evidence-based practice r = 0.64, p<0.05. Conclusion: These nurses were knowledgeable, active participants in evidence-based practice. Furthermore, there was a correlation between knowledge and evidence-based practice. Therefore, it is necessary to have solutions to provide or facilitate nurses to improve their knowledge of evidence-based practice, such as opening evidence-based practice courses for nurses and encouraging nurses to seek certifications in the field of evidence-based practice. authentication to apply in patient care.