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We investigated the influence of inositol triphosphate (IP3), trifluoperazine (TFP), and perhexiline on the calcium sensitivity of freeze-dried frog semitendinosus muscle fibres. Further, the effect of IP3 on calcium release from the sarcoplasmic reticulum (SR) of frog semitendinosus fibres skinned by saponin was studied. IP3 decreased the calcium sensitivity of freeze-dried frog skeletal muscle fibres and failed to induce a calcium release from SR of saponin-skinned fibres. Freeze-dried frog skeletal muscle fibres were strongly sensitized for calcium by TFP and perhexiline.

OBJECTIVE:To study all Caesarean myomectomies done at a tertiary center in South India. METHODS: 29 cases of Caesarean myomectomies were performed from 2004 to 2014, at our institution -a tertiary referral center. The type of fibroids, number and size of myomas, need for blood transfusions, and operating time and post-operative morbidity at Caesarean myomectomy were studied. RESULTS: We had equal number of subserous and intramural fibroids, and one large sub mucous fibroid removed at surgery. 7 fibroids were very large (> 10 cm diameter). 6 patients had more than 3 fibroids removed at surgery. 8 required blood transfusions, and none of our patients required hysterectomy. CONCLUSION: The authors find Caesarean myomectomy a feasible and safe option in women with fibroids undergoing Caesarean section. KEYWORDS: Caesarean myomectomy, leiomyomas in pregnancy. INTRODUCTION:The incidence of leiomyomas in pregnancy is 2-4%. Elective myomectomy at the time of Caesarean section has been traditionally discouraged due to the attendant morbidity, primarily from haemorrhage. If myomectomy during Caesarean section becomes widely accepted practice, it could eliminate the need for a second operation in these patients. Only few small randomized controlled studied are available, hence the proportion of surgeons attempting this combined procedure is low, due to concerns regarding safety. 1 At times, due to its location at the lower segment, large myoma removal is mandatory in order to deliver the baby, at Caesarean section. 2 British gynaecological surgeon Victor Bonney, who did extensive work on cancer cervix cases, also perfected the procedure of myomectomy and introduced his instrument also for use in the same -thereby conserving fertility of many fibroid patients, who till then were having hysterectomy. 3

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Twenty-three neurotic outpatients were examined and their symptoms evaluated by both their own and the doctor’s questionnaires. Strict outpatient-clinic routine was kept. Estimation was done on the patient’s expectations, motivations for treatment, as well as the doctor’s evaluation of the patient’s feelings and the doctor’s own feelings towards the patient. Results pointed to a good improvement rate in the lessening of anxiety and somatic concern by Oxazepam. No antagonistic influence on drug effect by motivational factors or feelings of the therapist could be detected.