Combining abilities of cotton varieties were evaluated using a line x tester mating design, twelve hybridswhich developed from 3 testers (male) and 4 lines (females). The experiment was conducted on Randomized Complete Block Design (RCBD) with three replications during 2014. The data were recorded for plant height, sympodial plant-1, bollsplant-1, boll weight and seed cotton yieldplant-1. Chandi-95, NIA-Ufaq and Sadori displayed the highest mean performance and GCA for more or less all the traits, indicating their superiority for inclusion in future breeding programme. The crosses Chandi-95 x BT 802, Sadori x BT A-1, Sohni x BT A-1 and NIA-Ufaq x BT-802 manifested meaning full SCA effects for economic traits, which could be used either for hybrid seed programme or developing superior varieties by applying selection in late segregating generations.