We developed a mild aromatic halogenation
reaction using a combination
of N-halosuccinimide and PhSSiMe3 or PhSSPh.
Less reactive aromatic compounds, such as methyl 4-methoxybenzoate,
were brominated with PhSSiMe3 or PhSSPh and N-bromosuccinimide in high yields. No reaction was observed in the
absence of PhSSiMe3 or PhSSPh. This method is also applicable
to chlorination reactions using N-chlorosuccinimide
and PhSSPh.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.