Summary We have correlated the morphological features of 30 human thyroid carcinomas with the cellular localisation of insulin-like growth factor 1 (IGF-1) mRNA and IGF-1 receptor peptide using in situ hybridisation with digoxigenin-labelled oligoprobes and immunohistochemistry. Four of the five follicular carcinomas studied showed a consistent, uniform, strong positivity for IGF-I mRNA in tumour cells compared with weakly positive surrounding normal follicular tissue and negative stroma. The majority of papillary carcinomas showed weak to moderate epithelial positivity for IGF-I mRNA and negative stroma. Immunohistochemistry for IGF-1 receptor showed moderate positivity confined to the tumour epithelial cells in both follicular and the majority of papillary carcinomas. However, in a subgroup of papillary carcinomas characterised by a diffuse stromal lymphoid infiltration (n = 5), the stromal cells showed a much stronger reactivity for IGF-1 mRNA than the tumour or background thyroid, and the tumour cells showed a uniformly high level of immunoreactivity for IGF-1 receptor. These results are compatible with the growth of the papillary carcinoma in these cases being the result of a symbiotic relationship between the stromal lymphoid cells and the tumour epithelium with the lymphoid cells responding to an antigen produced by the tumour cells and the tumour cells responding to a growth factor produced by the lymphoid infiltrate. We suggest that this mechanism may be important in other tumours. regularly associated with a widespread lymphoid infiltrate.

This study evaluated the profile of patients submitted to gastroplasty in the University Hospital of Maringá during 2008-2009. Clinical charts were analyzed to obtain clinical and laboratory data of all patients with morbid obesity submitted to gastroplasty. During the study period, 28 surgeries were performed, 57% of the patients lived in Maringá, 82% female, 40 years average age, with mean body mass index (BMI) of 46.7kg m-2. It was verified that 39% of the patients maintained an usual non-hypocaloric diet, 25% had quoted dietary reeducation, 36% were sedentary, and 29% practiced some physical activity, and remaining 1/3 of patients presented no data about lifestyle. Regarding associated pathologies, 79% were hypertensive, and 71% of patients presented fasting glucose above 100 mg dL-1, but only 12 of them had diagnosis of Type 2 diabetes mellitus. The hospital stay length was 4 days for 89% of the patients, and 11% had surgery complications. In this group of subjects, there was a clear preponderance of females and high prevalence of other pathologies. Identifying the profile of obese patients contributes to more effective decision-making and emphasizes the crucial role of multidisciplinary approach to health promotion and prevention of early and late complications of morbid obesity and gastroplasty.

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Objetivo: Caracterizar os adenomas hipofisários em relação ao perfil clínico e imunohistoquímico de uma população tratada cirurgicamente entre 1999 e 2013 no município de Maringá – PR e compará-los ao de outras instituições. Métodos: Estudo descritivo transversal realizado pela revisão de prontuários, analisando-se as seguintes variáveis: sexo, idade, sintomas, tamanho do tumor, padrão hormonal, imunohistoquímica e reintervenções neurocirúrgicas. Os resultados foram expressos em estatística descritiva. Resultados: A média de idade dos pacientes foi de 41,9 anos (mediana 42 anos), sendo 44 do sexo feminino (54%). Entre os tumores, 68 eram macroadenomas (84%) e 13 microadenomas (16%). A manifestação clínica mais frequente foi a alteração visual (47%), seguida de cefaleia (37%) e galactorréia (13,5%). Em relação ao padrão hormonal, 64 eram secretores (79%) e 17 eram não secretores (21%), sendo as imuno-histoquímicas mais frequentes prolactina (22%), null cell (21%), bi-hormonal PRL-GH (15%) e ACTH (11%). Quanto às reintervenções, 5 pacientes necessitaram de craniotomia (6%), 11 de nova cirurgia transesfenoidal (13,5%) e 3 de radioterapia (3,7%). Conclusão: Observou-se que, de um modo geral, o perfil de adenomas hipofisários dessa população é semelhante ao de outras instituições, com diferença em relação ao padrão hormonal que pode ser atribuída aos diferentes parâmetros para classificação.