Type version Original.Overweight and obesity associated with sedentary lifestyle can cause anatomical and functional changes with a higher risk of developing cardiometabolic changes, including in the pediatric population, which require early multiprofessional intervention. In this sense, the present study aimed to analyze the influence of an intervention with exergames on the anthropometric, biochemical, metabolic and cardiovascular parameters of overweight children. Twenty individuals of both sexes, with a mean age of 9.62 ± 0.91 years, with a clinical diagnosis of overweight were evaluated. Anthropometric parameters were evaluated: weight, height, body mass index (BMI), waist circumference (WC), skin folds in the supra-iliac region, subscapularis, biceps and triceps and percentage of body fat; biochemicals: total cholesterol and blood glucose; metabolic: basal metabolic rate (BMR) and bioimpedance; cardiovascular: blood pressure (BP) and heart rate variability (HRV) during a movement interception activity, using the MoveHero software. The HRV analysis occurred in three moments: rest (M1), activity (M2) and recovery (M3). Then, the intervention started with serious games style games, with an XBOX 360 device, whose game package used was Kinect Adventures® with the games: rapids, ricochet and top of reflections, with the heart rate (HR) being captured at each five minutes .Twenty sessions were held twice a week, lasting 60 minutes. For the reassessment, the same evaluation data were collected. For the assessment of HR during the intervention, the Karvonen formula (maximum HR = 220 -age) was considered and they were subjected to ANOVAs for repeated measures. For statistical analysis, the paired t-test between assessment and reassessment was used. In the HRV analysis, they were submitted to MANOVA, with factor 2 (evaluation and reevaluation) by 3 (M1, M2 and M3). The partial squared Eta (ŋp2) was reported to measure the size of the effect and interpreted as small, medium or large. Post hoc comparisons were performed using the LSD test (Least Significant Difference), with statistical significance when p <0.05. In the analysis of the results, in the anthropometric parameters significant differences were found in the percentage of fat (p = 0.020), skin fold of the right (p = 0.039) and left (p = 0.049) biceps. Regarding biochemical and metabolic parameters, no significant effects were found. Cardiovascular parameters found a significant effect on systolic blood pressure (p = 0.014). Regarding HRV, no differences were found in this population with the intervention performed, a fact that can be justified by the time of intervention or by the individuals' diagnosis. Thus, the use of exergames as a therapeutic strategy is feasible in overweight children, positively impacting health predictors and, consequently, helping to prevent future diseases. However, attention is needed to the time of execution of the intervention, in addition to the need for the association of guidelines and monitoring of a multidisciplinary health t...