Mild persistent bronchial asthma is a chronic inflammatory airway that cause the low oxygen saturation value (91-95%). Administering oxygen therapy, setting the position of the semi fowler and fowler can reduce the risk of a decreased chest configuration. This research aims to assess the difference of effectiveness of administering oxygen at semi fowler with fowler position to the saturation changes in mild persistent bronchial asthma patients in Ratu Zalecha Martapura Hospital. This research method is quasy Experiment. The population research are all patients who experience mild persistent bronchial asthma attack, the sample of this research are 20 respondents with purposive sampling technique and analyzed with independent T test. The results is at semi fowler position the average of oxygen saturation before the treatment is 93.10%, after administering oxygen therapy with semi fowler position the average saturation is 98.00%. At the fowler position the average of oxygen saturation before the treatment is 92.60%, after administering oxygen therapy with fowler position the average saturation is 98.00%. The independent T-test result showed no difference of effectiveness of administering oxygen at semi fowler with fowler position to the saturation changes in mild persistent bronchial asthma patients,so teh patients can be given both positions. AbstrakAsma bronkial persisten ringan merupakan inflamasi kronik jalan napas yang menyebabkan rendahnya nilai saturasi oksigen (91-95%). Pemberian terapi oksigen, pengaturan posisi semi fowler dengan fowler dapat mengurangi risiko penurunan pengembangan dinding dada. Penelitian ini bertujuan menilai perbedaan efektivitas pemberian oksigen pada posisi semi fowler dengan fowler terhadap perubahan saturasi pada pasien asma bronkial persisten ringan di RSUD Ratu Zalecha Martapura. Metode penelitian ini eksperimental dengan rancangan Quasy Experiment. Populasi dalam penelitian ini seluruh pasien yang mengalami serangan asma bronkial persisten ringan sebanyak 30 orang, sampel dalam penelitian sebanyak 20 orang dengan teknik Purposive sampling, dianalisis dengan uji T independen. Hasil penelitian pada posisi semi fowler rata-rata saturasi oksigen sebelum sebesar 93.10 %, setelah pemberian terapi oksigen