This study aims to: (1) Know the effect of Learning Cycle 7E learning model toward student learning outcomes with the help of powerpoint media and LKS on Xclass biodiversity material MIA in SMA Negeri 10 Palembang, (2) Knowing the difference between the learning outcomes using the model Learning Cycle 7E learning and Conventional learning. The research method used in the form of quasi -experiment (Quasi-experiment), using pretest-posttest group control design. The technique of collecting data by using test and observation sheet. The test is given before and after the treatment, while the observation sheet is given after the treatment. The data obtained were analyzed using paired sample t-test and independent sample t-test. T-test result paired sample t-test, followed by using formula omega and effect size d. While the results of t-test independent sample t-test, followed by using the formula effect size r. The subject of research is class X MIA at SMA Negeri 10 Palembang, sampling technique used is purposive sampling. The results obtained after using the t -test paired sample t-test, it is known that the significance value of 0.000 <0.05, which means Learning Cycle 7E learning model affects the learning outcomes of students with a percentage of 86%. While the result of t-test independent sample t-test, it is known that the significance value of 0.000 <0,05, which means there is a difference of final result between class which uses Learning Cycle 7E learning model using the conventional method and have percentage equal to 74%.Kata kunci: hasil belajar siswa, Learning Cycle 7E.