Multiple pregnancy and cervical shortening at 20-24 weeks of gestation was a stronger risk factor for preterm birth. Any pregnant woman being part-time employee or low educational level, having a male fetus and requiring steroid treatment should be watched for the development of preterm birth.

Habitual use of bidet toilets aggravates vaginal microflora, either by depriving normal microflora or facilitating opportunistic infection of fecal bacteria and other microorganisms.

This study shows that indomethacin increased the cytotoxicity of both CDDP and 5FUra by increasing the intracellular incorporation of free-CDDP and 5FUra, and suggests the effectiveness of indomethacin in reducing the dosage of CDDP and 5FUra or increasing CDDP and 5FUra cytotoxicity when these agents are given without reducing the dose.

Active ceruloplasmin in the cervicovaginal secretion might be a reliable clinical marker for term PROM.

The antitumor effect of indomethacin on Colon 26 tumor was investigated in conventional (CDF1) and nude mice (BALB/c nu/nu), and the telomerase activity in the tumor tissues treated with indomethacin was monitored. Growth of Colon 26 tumor was significantly suppressed with indomethacin treatment compared to the controls both in conventional and nude mice. And telomerase activity in the tumor tissues noticeably declined in contrast to normal somatic tissues (testis, liver and colon), which were not affected by indomethacin treatment. We also showed that indomethacin can suppress tumor growth in association with a preferential decrease in telomerase activity in tumor tissues both in conventional and nude mice to the same extent. This study suggests a method for investigating the mechanism of tumor suppression by indomethacin, and suggests that indomethacin might be useful as a novel agent for human cancer therapy.