Loss of Shh is an early change that occurs in the mucosa prior to neoplastic transformation. Its loss correlates with the type of IM and may play a role in carcinogenesis.

Diffuse-type NG depended on sex, and antral nodularity seemed to change from the diffuse to the nondiffuse type in association with atrophy.

Background. Spontaneous regression of non‐Hodgkin's lymphoma, occasionally reported in low grade groups, is a rare phenomenon in high grade groups. Clonal proliferation has not been confirmed in the majority of reported cases. In this woman, age 58 years, who had been diagnosed as having high grade immunoblastic lymphoma after excision of a single cervical lymph node, the remaining bilateral cervical, inguinal, and axillary adenopathy regressed completely without any cytotoxic treatments 22 days after biopsy. At the time of this writing, the patient has been free of disease for 24 months. Methods. Clonality of the lymphoproliferation in the case was examined by immunohistochemistry and poly‐merase chain reaction (PCR) amplification using paraffin embedded biopsy material. Possible implications of Epstein‐Barr virus in the pathogenesis of this process was examined also by PCR amplification and in situ hybridization. Results. The proliferating lymphoid cells showed restricted expression of immunoglobulin (Ig) light chain and amplification of clonally rearranged V‐D‐J regions of Ig heavy chain gene. Epstein‐Barr virus did not appear to be involved in the process. Conclusion. The present study shows that spontaneous complete regression of clonal lymphoproliferation that is morphologically a high grade lymphoma can occur.