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No histologic evidence suggests that intralaryngeal cidofovir or bevacizumab alone or in combination resulted in significant changes to the porcine vocal fold. Future studies may build on this model to test higher dosages and/or may combine injections with potassium titanyl phosphate laser therapy.

The prosthodontic literature is replete with articles addressing the reconstruction, psychological adaption, prosthesis success, quality of life, need for careful follow-up, and many other issues related to the patient who has undergone surgery, radiation, and/or chemotherapy for oral malignant neoplasms. However, in the prosthodontic professional literature, there is a paucity of information related to the early diagnosis and referral of lesions that may represent premalignant or malignant neoplasia. This article will describe the rationale, epidemiology, and appearance of oral premalignant and malignant mucosal lesions as well as the state-of-the-art diagnostic tools currently available to prosthodontists to ensure that their patients are diagnosed at the earliest possible time.In 2006, approximately 31,000 cases of oropharyngeal cancer were diagnosed in the United States, and about 25% of these patients died from their disease.1 The preponderance of these tumors represents squamous cell carcinoma of the oral mucous membranes. The combined 5-year survival rate in the United States is approximately 57%, and it has been established that less advanced disease increases the prognosis significantly.