Mild photoredox-catalyzed intramolecular cyclopropanation of alkenes with α-bromo-β-keto esters in an aqueous medium was developed. The sequential reaction process comprising intramolecular radical addition of α-bromo-β-keto esters to olefins under photoredox...

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Actumine A is a tetracyclic alkaloid isolated from the roots of Sinomenium acutum.Actumine A possesses selective T cell cytotoxicity, antiamnesic activity, and characteristic aza propellane core and spirocycle structure. In this review, total syntheses of actumine A are described, focusing on the construction of above mentioned structure.

Unsymmetric di­(heteroaryl)­ureas such as HetAr1-NHCONH-HetAr2 are efficiently synthesized from two symmetric ureas, HetAr1-NHCONH-HetAr1 and HetAr2-NHCONH-HetAr2, by rhodium-catalyzed exchange reactions. The equilibrium in some of the reactions can be shifted to the formation of unsymmetric ureas by the aggregation of the dimers formed by inter- and intramolecular hydrogen bonding.