The minimum weight dominating set problem (MWDSP) has been a popular research topic in recent years. The weights of vertexes may be considered as cost, time, or opponent’s payoff, which are uncertain in most cases. This paper discusses MWDSP under hybrid uncertain environments where the weights of vertexes are random fuzzy variables. First, random fuzzy theory is introduced to describe these hybrid uncertain variables. Then we propose three decision models based on three different decision criteria to solve MWDSP under hybrid uncertain environments. To solve the proposed models, we present a hybrid intelligent algorithm where random fuzzy simulation and genetic algorithm are embedded. Numerical experiments are performed in the last to show the robustness and effectiveness of the presented hybrid intelligent algorithm.